HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 4-Dimethylaminomethyl-2-hydroxymethylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-Bromo-4-(chloromethyl)thiazole | HCID 16427149 | — |
| Reactant | 2-Bromo-4-dimethylaminomethylthiazole | HCID 20402243 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Dimethylaminomethyl-2-hydroxymethylthiazole | HCID 20402155 | — |
Reaction Steps
An ethanol solution of dimethylamine is reacted with 2-bromo-4-chloromethylthiazole, prepared according to reference (4) above, and the resultant 2-bromo-4-dimethylaminomethylthiazole is treated with a strong base and formaldehyde according to the general procedure described in Acta. Chem. Scand., 20, 2649 (1966), to give the desired 4-dimethylaminomethyl-2-hydroxymethylthiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04380639 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-66f8451e8602423caa85ce0fae023232 |
| Source note | uspto-grants-1983_04 |