Sodium Hydroxide → HCID 178512718, compound

HRID 1702367Notes

Reaction equation

HRID 1702367 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.N(C1SC=C(CSCCN)N=1)C(N)=N.[NH:26]([C:30]1[S:31][CH:32]=[C:33]([CH2:35][S:36][CH2:37][CH2:38][NH:39][C:40]2[C:44]([O:45]C)=[N:43][S:42](=[O:48])(=[O:47])[N:41]=2)[N:34]=1)[C:27]([NH2:29])=[NH:28].[OH-].[Na+]>>[NH:26]([C:30]1[S:31][CH:32]=[C:33]([CH2:35][S:36][CH2:37][CH2:38][NH:39][C:40]2[C:44]([OH:45])=[N:43][S:42](=[O:48])(=[O:47])[N:41]=2)[N:34]=1)[C:27]([NH2:29])=[NH:28]

Participants

5

Reactant 4

HCID 14798Sodium HydroxideHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 178494332HCID 178494332, compoundHCID 1785127232-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine

Product 1

HCID 178512718HCID 178512718, compound

Procedure

When 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with one equivalent of 2-[(2-guanidinothiazol-4-yl)methylthio]ethylamine and the resultant 3-{2-[(2-guanidinothiazol-4-yl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with sodium hydroxide according to the procedure described in Example 17, Step B, the title compound is produced.

Sources & evidence

ORD record
ord-ef49a48a65444dfe92a789dba188e094
Source dataset
uspto-grants-1983_04
Patent number
US04380639

Reaction notes

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