反应详情

A solution of 62.0 gm (0.22 mol) of N-(2-chloro-3-pyridinyl)-1-methyl-4-nitro-1H-pyrazole-5-carboxamide in 1 liter of dioxane was hydrogenated in the presence of 5 gm of 10% palladium/animal charcoal as catalyst at room temperature and 5 bar until the hydrogen absorption was finished. After removal of the catalyst and the resulting precipitate by filtration, the filtrate was evaporated in vacuo. The remaining distillation residue was recrystallized from methanol.

1. custom5 bar until the hydrogen absorption
2. customAfter removal of the catalyst
3. filtrationthe resulting precipitate by filtration
4. customthe filtrate was evaporated in vacuo
5. distillationThe remaining distillation residue
6. customwas recrystallized from methanol