HCID 13121307, compound → HCID 13121308, compound

Participants

Reaction Steps

A suspension of 3-(ethoxycarbonyl)-4,9-dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester (2.2 g, described in example 3) in 5% aqueous HCl (v/v, 90 ml) was heated at reflux for 2 hr. The precipitate was collected by filtration and washed with water to give 1.4 g of the title compound; mp>250° C. (after recrystallization from ethanol); nmr (DMSO-d6) δ5.1 (s, 2H), 7.2 (m, 3H), 7.95 (m, 1H), 8.95 (s, 1H); ir (Nujol*) 2850, 1730, 1707, 1640 cm-1 ; uv λ max (MeOH) 344 nm (ε13,030), 235 (19,030); Anal Calcd for C13H9NO6 : C, 56.73% H, 3.30% N, 5.09%; Found: C, 56.76% H, 3.40% N, 5.05%.

Provenance & Evidence