Hydrochloric Acid → HCID 54284090, compound

Participants

Reaction Conditions

Reaction Steps

3.05 g (0.025 mole) of calcium chloride were added to 18.1 g (0.05 mole) of 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)-3-(methylcyclohex-3-en-1-yl)-2-propen-1-one in 100 ml of methanol, and the mixture was cooled to -20° C. 1.9 g (0.05 mole) of sodium borohydride were added in portions, and, when the addition had ended, the mixture was warmed to -10° C. Thereafter, an acetone/water mixture was added dropwise and the reaction mixture was allowed to warm to room temperature. It was adjusted to a pH value of 5 with dilute hydrochloric acid and concentrated. The residue was taken up in a mixture of methylene chloride/water and the organic phase was separated off, dried over sodium sulphate, filtered and concentrated. 15.6 g (85.7% of theory) of 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)-3-(methyl-cyclohex-3-en-1-yl)-2-propen-1-ol were obtained as an amorphous powder.

Provenance & Evidence