HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-2,3-bis(4-fluorophenyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Thiophene, 2,3-bis(4-fluorophenyl)- | HCID 11975814 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-2,3-bis(4-fluorophenyl)thiophene | HCID 13127253 | — |
Reaction Steps
A solution of 2,3-bis(4-fluorophenyl)thiophene (272 mg, 1 mmole) in 3 ml methylene chloride was diluted with 3 ml glacial acetic acid and cooled to 10°. A solution of 0.5 M bromine in acetic acid (1.1 ml) was added. After 21/2 hours an additional portion of bromine in acetic acid (1.1 ml) was added. After a total rection time of 51/2 hours, the reaction mixture was concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04381311 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-2611a991d4dc4ef6a78006123151b64d |
| Source note | uspto-grants-1983_04 |