HCID 13127255, compound → HCID 13127246, compound

Participants

Reaction Steps

A solution of 2-pentafluoropropionyl-4,5-bis(4-fluorophenyl)thiophene (5.83 g, 13.9 mmole) in 80 ml tetrahydrofuran was treated with 3 M methyl magnesium bromide (5.1 ml, 1.1 equiv.). After 3 hours, additional methyl magnesium bromide (2 ml) was added. After 4 hours total reaction time, the reaction was quenched with saturated aqueous NH4Cl and extracted with ethyl acetate. The combined organics were washed with brine, dried and concentrated in vacuo. Chromatography on silica gel gave the title compound as an oil (4.4 g).

Provenance & Evidence