HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 178485068, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| Reactant | N-cyano-N'-methyl-methylsulfinylformamidine | HCID 12918611 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178485068 | HCID 178485068 | 79.8% |
Reaction Steps
A solution of N-cyano-N'-methyl-methylsulfinylformamidine (493 mg) and 2-(5-methylimidazol-4-ylmethylthio)ethylamine (684 mg) in CH3CN (20 ml) was stirred for 4 hrs. at room temperature. After concentration under a reduced pressure, the residue was subjected to chromatography on SiO2 [eluant: CH3CN-CH3OH (4:1)]. The product obtained was recrystallized from CH3CN to give N"-cyano-N-methyl-N'-[2-(5-methylimidazol-4-ylmethylthio)ethyl]guanidine (684 mg). Yield 79.7%, m.p. 136°-138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04381395 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-09bcb5e5932c49c6b3c644ad3fd9fb80 |
| Source note | uspto-grants-1983_04 |