Hydrazine hydrate (1:1) → HCID 15572795, compound

Participants

Reaction Steps

In this example, 4 g of 1-(4-ethoxycarbonylmethylphenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol (Compound 14) is dissolved in 30 ml of ethanol and 6.1 g of 85% hydrazine hydrate is added thereto. The mixture is heated under reflux for 2 hours. The solvent is distilled away from the reaction solution under reduced pressure. The residue is recrystallized from tetrahydrofuran-ether to obtain 1.6 g of 1-(4-hydrazinocarbonylmethylphenoxy) -3-(1-methyl-3-phenylpropylamino)-2-propanol. (Yield: 42%),

Provenance & Evidence