Bromine → HCID 942132, compound

HRID 1702502Notes

Reaction equation

HRID 1702502 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]([C:10](=[O:12])[CH3:11])=[C:8]([CH3:9])[C:4]=2[CH:3]=1.[Br:15]Br>C(O)(=O)C>[F:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]([C:10](=[O:12])[CH2:11][Br:15])=[C:8]([CH3:9])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 203892031-(5-Fluoro-3-methyl-1-benzofuran-2-yl)ethan-1-one

Product 1

HCID 942132HCID 942132, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In this Reference Example, 38.4 g of 5-fluoro-3-methyl-2-acetylbenzo [b] furan is dissolved in 200 ml of acetic acid and 32.0 g of bromine is added dropwise thereto at room temperature. The mixture solution is then stirred for 30 minutes at room temperature, whereby the color of bromine disappears and crystals are deposited from the solution. Then, the solution is filtered to obtain 38.0 g of 5-fluoro-3-methyl-2-(α-bromoacetyl) benzo [b] furan as crystals. (Yield: 70%). Melting point of the desired compound recrystallized from ethanol is 120°-123° C.

Workup

  1. customat room temperature
  2. filtrationThen, the solution is filtered

Sources & evidence

ORD record
ord-fe485438c543402bb785b4c7e8c1206c
Source dataset
uspto-grants-1983_04
Patent number
US04381398

Reaction notes

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