HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 15581074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 1-(2-Amino-3-methylphenyl)ethan-1-one | HCID 179628 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15581074 | HCID 15581074 | — |
Reaction Steps
2-Methyl-6-acetylaniline (25 g) and pyridine (26.5 g) in 1 liter methylene chloride were cooled in an ice-acetone bath. A solution of chloroacetyl chloride (37.9 g) in 100 ml methylene chloride was dripped in slowly. The solution was stirred at room temperature for 2 hours, washed with 10% HCl, 10% NaOH, dried (MgSO4) and stripped. Yield: the title product as a white solid, MP 88°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04348222 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-de99c0cd8ba944329885ce68dacd6502 |
| Source note | uspto-grants-1982_09 |