HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(t-Butyldimethylsilyl)-4-(2-oxoethyl)-2-azetidinone → 2-Azetidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(t-Butyldimethylsilyl)-4-(2-oxoethyl)-2-azetidinone | HCID 12804718 | — |
| Reactant | HCID 178491912 | HCID 178491912 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Azetidinone | HCID 136721 | — |
| Product | HCID 178491912 | HCID 178491912 | — |
Reaction Steps
Treatment of 1-(t-butyldimethylsilyl)-4-(2-oxoethyl)-2-azetidinone (0.01 mole) with p-methoxyphenyl-magnesium bromide (1.1 eq.; in ether at 0° C. gives 2-azetidinone with p-methoxyphenyl-magnesium bromide gives 1-(t-butyl dimethylsilyl)-4-(2-hydroxyethyl-2-p-methoxyphenyl)-2-azetidinone which is acetylated as described before (Ex. 3, Step C) to give 4-(2-acetoxy-2-p-methoxyphenyl)-2-azetidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04348320 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-4fb70e7df10b49e493f0dfc805253f72 |
| Source note | uspto-grants-1982_09 |