反应详情

A suspension of 1.0 g. of 5-isopropoxyanthranilic acid, 1.1 g. of 6-chloro-3-pyridinemethanol benzoate and 0.01 g. of potassium iodide in 10 ml. of triglyme was heated to 150° overnight under a stream of argon. On cooling, the reaction mixture was dissolved in hot methanol, filtered and evaporated to an orange oil. Chromatographic separation and recrystallization from hexane-dichloromethane yielded 8-hydroxymethyl-2-isopropoxy-11H-pyrido[2,1-b]quinazoline-11-one benzoate, mp 123°-126°.

1. additionA suspension of 1.0 g
2. temperatureOn cooling
3. filtrationfiltered
4. customevaporated to an orange oil
5. customChromatographic separation and recrystallization from hexane-dichloromethane