Azobisisobutyronitrile → HCID 20526231, compound

Participants

Reaction Steps

German Laid-Open Application DOS 2,720,654 discloses that alkanecarboxylic acid derivatives, for example tert.-butyl 4-chlorophenoxyacetate, can be reacted with N-bromosuccinimide in the presence of a solvent and of a source of free radicals, such as dibenzoyl peroxide or azo-bis-isobutyronitrile, to give tert.-butyl bromo-(4-chlorophenoxy)-acetate. In the case of tert.-butyl 4-chlorophenoxyacetate it is stated that a reaction time of 2 hours is required and a yield of 76 percent is obtained. If the process is carried out with the corresponding propionic acid esters, especially on an industrial scale, substantially longer reaction times, for example from 8 to 15 hours, are required to obtain yields of from 60 to 80% of theory.

Provenance & Evidence