Aluminium lithium hydride → HCID 20525813, compound

HRID 1702679Notes

Reaction equation

HRID 1702679 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31](OCC)=[O:32])=[CH:26][CH:25]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>C(OCC)C>[CH2:7]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][OH:32])=[CH:26][CH:25]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54054771HCID 54054771, compound

Product 1

HCID 20525813HCID 20525813, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A mixture of 1.0 g. of lithium aluminum hydride in 20 ml. of dry ethyl ether is stirred at room temperature as a solution of 5.0 g. of ethyl (4-hexadecylaminophenyl)acetate in 15 ml. of dry ethyl ether is slowly added. When the addition is complete, the reaction is stirred for an additional 2 hours and then quenched with 10% aqueous ammonium chloride. The mixture is filtered through celite, the phases are separated, and the ether is evaporated to provide 2-(4-hexadecylaminophenyl)ethanol.

Workup

  1. additionA mixture of 1.0 g
  2. additionWhen the addition
  3. customquenched with 10% aqueous ammonium chloride
  4. filtrationThe mixture is filtered through celite
  5. customthe phases are separated
  6. customthe ether is evaporated

Sources & evidence

ORD record
ord-b73a586f701640df93a502c8ddc95513
Source dataset
uspto-grants-1982_09
Patent number
US04348399

Reaction notes

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