Ammonia → HCID 20525748, compound

HRID 1702689Notes

Reaction equation

HRID 1702689 reaction equation
Cl.[CH2:2]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](Cl)=[O:27])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[NH3:29]>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([NH2:29])=[O:27])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20525749HCID 20525749, compound

Product 1

HCID 20525748HCID 20525748, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A sample of (4-hexadecylaminophenyl)acetyl chloride hydrochloride is slurried in methylene chloride at 0° as anhydrous ammonia gas is bubbled in for one half hour. At the end of this time, the reaction mixture is washed with water and then aqueous sodium bicarbonate. The organic phase is then dried, filtered and evaporated, providing 2-(4-hexadecylaminophenyl)acetamide.

Workup

  1. customis bubbled in for one half hour
  2. washAt the end of this time, the reaction mixture is washed with water
  3. customThe organic phase is then dried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-10ec1852a76142dcbb79b48baaea7d67
Source dataset
uspto-grants-1982_09
Patent number
US04348399

Reaction notes

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