HRID1702701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6212

Chloroform

CHCl3

HCID8471

Triethylamine

C6H15N

HCID103574

Ethyl 1,3-thiazolidine-4-carboxylate

C6H11NO2S

结构：CCCCCCCCCCCCCCCCNc1ccc(C=CC(=O)Cl)cc1.Cl

HCID73682495

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCNc1ccc(C=CC(=O)N2CSCC2C(=O)OCC)cc1

HCID54423945

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

One-tenth mole of 4-(hexadecylamino)cinnamoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile.

WORKUP

后处理

filtrationAfter 5 hours at 20° C. the solution is filtered
customevaporated to a white solid which
customis recrystallized from acetonitrile

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db49e442d3e84cef8558d12d05b7c08f
来源数据集: uspto-grants-1982_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04348399
来源说明: uspto-grants-1982_09

反应 SMILES

Cl.[CH2:2]([NH:18][C:19]1[CH:29]=[CH:28][C:22]([CH:23]=[CH:24][C:25](Cl)=[O:26])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[S:30]1[CH2:34][CH:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[NH:32][CH2:31]1.C(Cl)(Cl)Cl.C(N(CC)CC)C>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:29]=[CH:28][C:22]([CH:23]=[CH:24][C:25]([N:32]2[CH:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:34][S:30][CH2:31]2)=[O:26])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]