HCID 70508431, compound → HCID 70507453, compound

HRID 1702711Notes

Reaction equation

HRID 1702711 reaction equation
[CH3:1][CH:2]1[CH:6]([C:7]([O:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])[N:5]2[C:23](=[O:25])[CH2:24][C@H:4]2[C:3]1=[O:26]>C(Cl)Cl>[OH:26][CH:3]1[C@@H:4]2[CH2:24][C:23](=[O:25])[N:5]2[CH:6]([C:7]([O:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:8])[CH:2]1[CH3:1]

Participants

3

Reactant 1

HCID 70508431HCID 70508431, compound

Product 1

HCID 70507453HCID 70507453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By the procedures of Example 3, benzhydryl 2-methyl-1-oxocarbapenam-3-carboxylate (53 mg. in 3 ml. of methylene chloride employing only the 10 mg. reducing agent initially charged) was converted to purified benzhydryl 1-hydroxy-2-methylcarbapenam-3-carboxylate [53 mg.; Rf 0.30 (4:1 chloroform:ethyl acetate)].

Workup

  1. additioninitially charged)
  2. customto purified benzhydryl 1-hydroxy-2-methylcarbapenam-3-carboxylate [53 mg.; Rf 0.30 (4:1 chloroform:ethyl acetate)]

Sources & evidence

ORD record
ord-3ff599e2663b4fecbcdc5bc913c8687b
Source dataset
uspto-grants-1982_09
Patent number
US04348264

Reaction notes

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