Methyl Isocyanate → HCID 20525183, compound

Participants

Reaction Steps

5.7 g (0.1 mol) of methyl isocyanate and a few drops of dibutyl-tin dilaurate were added to 25.8 g (0.1 mol) of 1-(2,4-dichlorophenyl)-1-hydroxy-2-(imidazol-1-yl)-ethane in 250 ml of benzene, while stirring. The mixture was stirred overnight at 60°-65° C. It was then allowed to cool and the crystalline precipitate was filtered off and rinsed with ether. 25.5 g (81% of theory) of 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)-methylcarbamoyloxy-ethane of melting point 106°-108° C. were obtained.

Provenance & Evidence