HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(N',N'-diethylcarbamoyl)ethyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Butanoic acid, 4-(diethylamino)-4-oxo- (9CI) | HCID 15205 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-(N',N'-diethylcarbamoyl)ethyl isocyanate | HCID 20525048 | — |
Reaction Steps
The reaction of 3-(N,N-diethylcarbamoyl)propionic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-(N',N'-diethylcarbamoyl)ethyl isocyanate (I.R.: 2290 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-[2-(N',N'-diethylcarbamoyl)ethyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-e3ea8f59aac94313a99d07ca2aee7126 |
| Source note | uspto-grants-1982_09 |