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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1702779Generated: October 26, 2026

Triethylamine → 3-isocyanato-N,N-dipropylpropanamide

https://huagongshe.com/reaction/1702779

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
ReactantP,P-Diphenylphosphinic azideHCID 199401—
Reactant3-(Dipropylcarbamoyl)propanoic acidHCID 16772313—
SolventBenzeneHCID 241—
Product3-isocyanato-N,N-dipropylpropanamideHCID 20525060—

Reaction Steps

The reaction of 3-(N,N-dipropylcarbamoyl)propionic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-(N',N'-dipropylcarbamoyl)ethyl isocyanate (I.R.: 2280 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-[2-(N',N'-dipropylcarbamoyl)ethyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 4.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04349552
Source datasetuspto-grants-1982_09
ORD IDord-59938204a81544e5824d608441571880
Source noteuspto-grants-1982_09