HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → [(2-Isocyanatoethyl)thio]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | HCID 178526170 | HCID 178526170 | — |
| Product | [(2-Isocyanatoethyl)thio]benzene | HCID 20525097 | — |
Reaction Steps
The reaction of 3-phenylthiopropionic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 2-phenylthioethyl isocyanate (I.R.: 2260 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-(2-phenylthioethyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-6c630ab939424b77a18c7d2b822bcb98 |
| Source note | uspto-grants-1982_09 |