HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → HCID 20525063, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | 2-Thiopheneacetic acid | HCID 15970 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 2-(Isocyanatomethyl)thiophene | HCID 15890621 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 20525063 | HCID 20525063 | — |
Reaction Steps
The reaction of 2-thienylacetic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 2-thienylmethyl isocyanate, which was reacted with 5-fluorouracil to provide 1-[N-(2-thienylmethyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-021b7776ade44bd6b66e3ac32936d287 |
| Source note | uspto-grants-1982_09 |