HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → HCID 20525065, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | HCID 20525123 | HCID 20525123 | — |
| Reactant | HCID 43470113 | HCID 43470113 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 20525065 | HCID 20525065 | — |
Reaction Steps
The reaction of 6-[(2,5-dioxopyrrolidin-1-yl)hexanoic acid and diphenylphosphoryl azide in a solutuon of triethyl amine and benzene provided a solution comprising 5-(2,5-dioxopyrrolidin-1-yl)pentyl isocyanate, which was reacted with 5-fluorouracil to provide 1-[N-[5-(2,5-dioxopyrrolidin-1-yl)pentyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-8bfbaa192a15439da68d88b2c0638930 |
| Source note | uspto-grants-1982_09 |