HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → HCID 20525081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 6-((tert-Butoxycarbonyl)amino)hexanoic acid | HCID 637602 | — |
| Reactant | Carbamic acid, (5-isocyanatopentyl)-, 1,1-dimethylethyl ester | HCID 22010098 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 20525081 | HCID 20525081 | — |
Reaction Steps
The reaction of 6-t-butoxycarbonylaminohexanoic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 5-t-butoxycarbonylaminopentyl isocyanate, which was reacted with 5-fluorouracil to provide 1-[N-(5-t-butoxycarbonylaminopentyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-28045779fe9a4cd7940726908b7cbdac |
| Source note | uspto-grants-1982_09 |