5-Fluorouracil → HCID 20525083, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-fluorouracil (2.6 g.) in N,N-dimethylacetoamide (10 ml.) was added to oily 2-tetrahydrothiophenyl isocyanate (3.1 g.). The mixture was stirred at 50° C. for 8 hours and concentrated in vacuo. The residue was treated with water (80 ml.) to give crystalline precipitates, which were collected by filtration and dried over phosphoric anhydride to give 1-[N-(2-tetrahydrothienyl)carbamoyl]-5-fluorouracil (3.68 g.); pale yellow crystalline powder.

Provenance & Evidence