5-Fluorouracil → HCID 20525058, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-fluorouracil (2.6 g.) in pyridine (25 ml.) was added to 4-chlorophenyl isocyanate (3.07 g.) and the solution was stirred at 80° C. for 4 hours. The resultant solution was allowed to stand overnight in a refrigerator. The crystalline precipitates were collected by filtration, washed successively with ethyl acetate, diethyl ether, and then dried to give 1-[N-(4-chlorophenyl)carbamoyl]-5-fluorouracil (3.30 g.); colorless crystalline powder.

Provenance & Evidence