5-Fluorouracil → HCID 20525101, compound

Participants

Reaction Conditions

Reaction Steps

5-Fluorouracil (3.30 g.) was added to the solution of 3-(2-thienyl)propyl isocyanate and stirred at 100° C. for 2 hours. The resultant mixture was evaporated to dryness under reduced pressure. The residue was dissolved in ethyl acetate, washed with water, dried over magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized from ethanol to give colorless plate 1-[N-[3-(2-thienyl)propyl]carbamoyl]-5-fluorouracil (2.3 g.).

Provenance & Evidence