Pyridine → HCID 20525078, compound

Participants

Reaction Conditions

Reaction Steps

Diphenylphosphoryl azide (6.41 g.) was added dropwise to a solution of 3-methyladamantan-1-ylacetic acid (4.85 g.) in dry pyridine (20 ml.) and stirred at 100° C. for 40 minutes to give 3-methyladamantan-1-ylmethyl isocyanate [I.R.: 2260 cm-1 ]. 5-Fluorouracil (2.52 g.) was added to the solution and stirred at 100° C. for 2 hours. The resultant mixture was evaporated under reduced pressure. The residue was dissolved in ethyl acetate and washed with dilute hydrochloric acid and water. Ethyl acetate layer was dried over magnesium sulfate, filtered and evaporated to give residue, which was recrystallized from ethanol to give colorless crystals of 1-[N-(3-methyladamantan-1-ylmethyl)carbamoyl]-5-fluorouracil. (984 mg.)

Provenance & Evidence