HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1-[N-(3-bromoadamantan-1-ylmethyl)carbamoyl]-5-fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 2-(3-Bromoadamantan-1-yl)acetic acid | HCID 2728837 | — |
| Reactant | 3-Bromoadamantan-1-ylmethyl isocyanate | HCID 20525066 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-[N-(3-bromoadamantan-1-ylmethyl)carbamoyl]-5-fluorouracil | HCID 20525072 | — |
Reaction Steps
The reaction of 3-bromoadamantan-1-ylacetic acid and diphenyl phosphoryl azide in dry pyridine provided a solution comprising 3-bromoadamantan-1-ylmethyl isocyanate [I.R.: 2270 cm-1 ], which was reacted with 5-fluorouracil to provide 1-[N-(3-bromoadamantan-1-ylmethyl)carbamoyl]-5-fluorouracil substantially by the similar method to that of Example 45.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-1caca980f0c44a7f8cc8aeebf5ffa6d4 |
| Source note | uspto-grants-1982_09 |