HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1-[N-(2-Adamantylmethyl)carbamoyl]-5-fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 2-(Adamantan-2-yl)acetic acid | HCID 870990 | — |
| Reactant | 2-Adamantylmethyl isocyanate | HCID 20525073 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-[N-(2-Adamantylmethyl)carbamoyl]-5-fluorouracil | HCID 20525043 | — |
Reaction Steps
The reaction of 2-adamantylacetic acid and diphenyl phosphoryl azide in dry pyridine provided a solution comprising 2-adamantylmethyl isocyanate [I.R.: 2260 cm-1 ], which was reacted with 5-fluorouracil to provide 1-[N-(2-adamantylmethyl)carbamoyl]-5-floururacil substantially in the similar method to that of Example 45.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-866643fcacb14e62b407509b681ccefa |
| Source note | uspto-grants-1982_09 |