HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethanone, 1-(4-(4-(methylsulfonyl)phenoxy)phenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 1-(Methanesulfonyl)-4-phenoxybenzene | HCID 13078515 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethanone, 1-(4-(4-(methylsulfonyl)phenoxy)phenyl)- | HCID 514879 | 88.9% |
Reaction Steps
To a solution of 5.0 g (0.0202 mole) of 1-(4-(methylsulfonyl)phenoxy)benzene and 2.20 g (0.0280 mole) of acetyl chloride dissolved in 35 ml of methylene chloride (CH2Cl2) was slowly added 6.70 g (0.0503 mole) of anhydrous aluminum chloride. The mixture was heated at reflux for 45 minutes, cooled and poured over ice and concentrated hydrochloric acid (conc. HCl). Additional CH2Cl2 was added and the organic layer separated, washed with water and dried (Na2SO4). Removal of solvent in vacuo yielded 5.2 g (88.9% yield) of purified 1-(4-(4-(methylsulfonyl)phenoxy)phenyl)ethanone, mp 131°-132.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349568 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-8663102003e24bfa87a076bf45f3fd5e |
| Source note | uspto-grants-1982_09 |