Potassium Carbonate → HCID 13078523, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12.1 g (0.100 mole) of 4-fluorobenzonitrile, 21.0 g (0.150 mole) of 4-(methylthio)phenol, 20.7 g (0.150 mole) of anhydrous potassium carbonate (K2CO3) and 150 ml of hexamethyl phosphoramide was heated at 100° C. for 4 hrs. The reaction mixture was cooled and poured into a solution of 200 ml of 20% aqueous NaOH and 500 ml of water. The crystalline product was collected by filtration and washed well with water. The product was dissolved in CH2Cl2 and dried (Na2SO4). Removal of solvent in vacuo afforded 11.3 g (46.9% yield) of product. Recrystallization from hexane gave purified 4-(4-(methylthio)phenoxy)benzonitrile, mp 65°-66° C.

Provenance & Evidence