Methylthiourea → HCID 178470156, compound

HRID 1702842Notes

Reaction equation

HRID 1702842 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([Cl:16])=[N:8][C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])[CH3:2].[CH3:17][NH:18][C:19]([NH2:21])=[S:20]>CC(C)=O>[ClH:16].[CH2:1]([O:3][C:4]([C:6]1[C:7]([S:20][C:19](=[NH:21])[NH:18][CH3:17])=[N:8][C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 2723704MethylthioureaHCID 12283436Ethyl 3-Chloroquinoxaline-2-carboxylate

Product 1

HCID 178470156HCID 178470156, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (4.733 g., 0.02 mole) and 1.803 g. (0.02 mole) of monomethylthiourea were dissolved in 100 ml. of acetone and the solution as stirred at reflux for 11/2 hours, cooled, and filtered to give 5.62 g. of crude solid. Extraction of the crude solid with boiling acetonitrile left 3.14 g. of insoluble product, m.p. 180° (dec.).

Workup

  1. temperatureat reflux for 11/2 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. customto give 5.62 g
  5. extractionExtraction of the crude solid with boiling acetonitrile
  6. waitleft 3.14 g

Sources & evidence

ORD record
ord-a45b7f65169e4004b1d3e2f332892734
Source dataset
uspto-grants-1982_09
Patent number
US04349674

Reaction notes

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