N,N'-Diethylthiourea → 2-[Ethylamino(ethylimino)methylthio]-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride

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Reaction Steps

2-Chloro-3-quinoxalinecarboxylic acid, ethyl ester (7.100 g., 0.03 mole) and 3.967 g., (0.03 mole) of 1,3-diethylthiourea were dissolved in 150 ml. of acetone and boiled in an open flask for 1 hour. The reaction mixture was stirred at room temperature for 1 hour, then concentrated to a volume of 50 ml. After standing at room temperature overnight, the mixture was filtered and the solid residue washed with acetone and ether. Recrystallized from a mixture of methanol, acetone and ether it gave 7.182 g. product, m.p. 144.5°-145° C.

Provenance & Evidence