反应详情

2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (3.551 g., 0.015 mole) and 2.405 g. (0.015 mole) of 1,3-di-n-propylthiourea were dissolved in acetone and heated at reflux for 11/2 hours. The solution was concentrated to a volume of 50 ml. and cooled. A small amount of solid was removed by filtration. The filtrate was further concentrated to a volume of 25 ml. and ether was added to turbidity. After the reaction mixture had been cooled the yellow solid was collected by filtration to give 2.77 g. (46.6%) of the product, m.p. 129°-130° C.

1. temperatureheated
2. temperatureat reflux for 11/2 hours
3. concentrationThe solution was concentrated to a volume of 50 ml
4. temperatureand cooled
5. customA small amount of solid was removed by filtration
6. concentrationThe filtrate was further concentrated to a volume of 25 ml
7. additionand ether was added to turbidity
8. temperatureAfter the reaction mixture had been cooled the yellow solid
9. filtrationwas collected by filtration
10. customto give 2.77 g