Ammonia → 3-Chloro-5-(trifluoromethyl)-2-pyridinamine

HRID 1702865Notes

Reaction equation

HRID 1702865 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[NH3:13]>>[NH2:13][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 6072483-Chloro-5-(trifluoromethyl)-2-pyridinamine

Procedure

6.5 g of 2,3-dichloro-5-trifluoromethylpyridine and 20 ml of 28% aqueous ammonia were placed in a 50 ml autoclave, and the mixture was reacted for 24 hours at 100° C., and further for 5 hours at 125° C. (inner pressure: about 2 atms.). After completion of the reaction, the reaction product was allowed to cool to obtain crystals. The thus obtained crystals were then washed with water and dried to obtain 1.5 g of 2-amino-3-chloro-5-trifluoromethylpyridine having a melting point of 90° to 92° C.

Workup

  1. customthe mixture was reacted for 24 hours at 100° C.
  2. customAfter completion of the reaction
  3. temperatureto cool
  4. customto obtain crystals
  5. washThe thus obtained crystals were then washed with water
  6. customdried

Sources & evidence

ORD record
ord-8909163a10bf48baa830015af7b0ba2a
Source dataset
uspto-grants-1982_09
Patent number
US04349681

Reaction notes

Loading…