Sodium hydride → 8-[3-(4-Chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester

HRID 1702884Notes

Reaction equation

HRID 1702884 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:13][NH:12][C:11]2=[O:21])=[CH:6][CH:5]=1.[CH3:22][O:23][C:24](=[O:33])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br>CN(C=O)C>[CH3:22][O:23][C:24](=[O:33])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:12]1[CH:13]=[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]([C:7]2[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=2)[C:11]1=[O:21]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 124189881-(4-Chlorophenyl)-5-phenyl-4-imidazolin-2-one

Product 1

HCID 537272038-[3-(4-Chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 2.4 g of NaH (80% suspension in mineral oil), 21.6 g of 1-(4-chlorophenyl)-5-phenyl-4-imidazolin-2-one, 160 cc. of DMF, 19.0 g of 8-bromocaprylic acid methyl ester and 2.4 g of NaJ.

Workup

  1. customThe product is produced

Sources & evidence

ORD record
ord-7c3f831edb2f4b4290cd9e8903598d1d
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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