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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 170290Generated: October 29, 2026

Tetrahydrofuran → 6-Chloro-5-fluoro-2-(2-fluoro-4-trimethylsilanyl-phenylamino)-nicotinic acid

https://huagongshe.com/reaction/170290

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantLithium ionHCID 28486—
Reactant2,6-Dichloro-5-fluoronicotinic acidHCID 2733659—
ReactantNpc316347HCID 3280088—
Reactant2-Fluoro-4-(trimethylsilyl)anilineHCID 59596599—
Product6-Chloro-5-fluoro-2-(2-fluoro-4-trimethylsilanyl-phenylamino)-nicotinic acidHCID 59140133—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-378e61f0d5454e16a42bc85e7d2905a7
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)