Sodium Hydroxide → HCID 12961716, compound

HRID 1702901Notes

Reaction equation

HRID 1702901 reaction equation
C[O:2][C:3](=[O:30])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:13]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[C:12]1=[O:29].[OH-].[Na+]>CO>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([N:13]2[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:15][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:30])=[O:2])[C:12]2=[O:29])=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 537272038-[3-(4-Chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester

Product 1

HCID 12961716HCID 12961716, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product is produced as described in example 18 from 20 g of 8-[3-(4-chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester and 1.88 g of NaOH in 100 cc. of methanol. Further purification by chromatography on silicic acid gel using a mixture of hexane annd ethyl acetate as eluant.

Workup

  1. customThe product is produced
  2. customFurther purification by chromatography on silicic acid gel
  3. additiona mixture of hexane annd ethyl acetate as eluant

Sources & evidence

ORD record
ord-13f7b9946e2943e281e8b6aa375294be
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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