Sodium Hydroxide → HCID 12961720, compound

HRID 1702905Notes

Reaction equation

HRID 1702905 reaction equation
C[O:2][C:3](=[O:30])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:13]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:12]1=[O:29].[OH-].[Na+]>CO>[F:28][C:25]1[CH:26]=[CH:27][C:22]([N:13]2[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:15][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:30])=[O:2])[C:12]2=[O:29])=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 542655478-[3-(4-Fluorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester

Product 1

HCID 12961720HCID 12961720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product is produced as described in example 18 from 16.4 g of 8-[3-(4-fluorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] caprylic acid methyl ester and 1.6 g of NaOH in 80 cc. of methanol. Further purification by chromatography on silicic acid gel using chloroform as eluant.

Workup

  1. customThe product is produced
  2. customFurther purification by chromatography on silicic acid gel

Sources & evidence

ORD record
ord-8014c48a7ce047158bb65b41cf5fc3ca
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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