Thionyl Chloride → HCID 54165256, compound

Participants

Reaction Conditions

Reaction Steps

1 g of [3-(4-chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] acetic acid are dissolved in a small amount of anhydrous chloroform. 0.7 g of thionylchloride are added thereto and the mixture is stirred at about 50° C. for 2 hours. The mixture is evaporated in a vacuum, the residue is mixed with a small amount of chloroform and 0.31 g of hexanol are added to the mixture. After stirring for one hour at room temperature, the CHCl3 -solution is first extracted with an NaHCO3 -solution and then with water. It finally is dried over Na2SO4. The CHCl3 -solution is evaporated, remaining hexanol is distilled off a high vacuum and the residue is further purified chromatographically on silicic acid gel using CHCl3 as eluant.

Provenance & Evidence