Water → HCID 10702206, compound

Temperature

55 °C

2.2 g of the product of Step A were added to a mixture of 1.8 ml of 22° Be hydrochloric acid in 18 ml of water and the mixture was heated at 55° C. for 17 hours and was then cooled to 20° C. The mixture was extracted with ethyl acetate and the organic phase was washed with 2 N aqueous sodium hydroxide solution. The alkaline aqueous phase was washed with methylene chloride, with ethyl acetate and was acidified to a pH of 3.5 by addition of 2 N hydrochloric acid. The mixture was extracted with ethyl acetate and the organic phase was washed with water, dried and evaporated to dryness. The residue was taken up in ether and the mixture was vacuum filtered to obtain 0.450 g of (3S,3aS,4R,7S,7aR) 3-hydroxy-3a, 4,7,7a-tetrahydro-1H,3H-4,7-methano-isobenzofuran-1-one melting at 133° C. and having specific rotation of [α]D20 =-44° (c=1% in benzene).

1. temperaturewas then cooled to 20° C
2. extractionThe mixture was extracted with ethyl acetate
3. washthe organic phase was washed with 2 N aqueous sodium hydroxide solution
4. washThe alkaline aqueous phase was washed with methylene chloride, with ethyl acetate
5. additionwas acidified to a pH of 3.5 by addition of 2 N hydrochloric acid
6. extractionThe mixture was extracted with ethyl acetate
7. washthe organic phase was washed with water
8. customdried
9. customevaporated to dryness
10. filtrationfiltered

ORD record

ord-74ef9e0445984a73978c480e2cd0dc5e

Source dataset

uspto-grants-1982_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04350637