HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Succinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Succinyl chloride | HCID 10970 | — |
| Reactant | Pentanedioyl dichloride | HCID 17887 | — |
| Reactant | Bruceolide | HCID 99531 | — |
| Reactant | Methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17R)-10,15,16-trihydroxy-9,13-dimethyl-3-(3-methylbut-2-enoyloxy)-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate | HCID 12302104 | — |
| Product | Succinate | HCID 160419 | — |
| Product | Glutarate(2-) | HCID 4418048 | — |
| Product | 3,5-Dioxohexanoic acid | HCID 5459844 | — |
Reaction Steps
In accordance with the above procedure, but where, in place of 3,4-dimethyl-2-pentenoyl chloride, there is utilized benzoyl chloride, trimethoxybenzoyl chloride or cinnamoyl chloride there is obtained the corresponding 3-ester or 3,15-diester. Similarly, but where, in place of bruceolide, there is utilized brusatol and as an acid chloride there is utilized succinoyl chloride, glutaroyl chloride and acetyl chloride, there is obtained 3,3-bisbrusatolyl succinate, 3,3-bisbrusatolyl glutarate and 3,11,12-brusatolyl triacetate, 3, 11, 12 bis brusatolyl triacetate can also be prepared by acetylation with pyridine in acetic anhydride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04350638 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-233cfa63431c469c810679ed744ad36f |
| Source note | uspto-grants-1982_09 |