Nitric Acid → HCID 178526469, compound

Participants

Reaction Steps

A cooled mixture of 70 ml of concentrated sulfuric acid and 35 ml of concentrated nitric acid was added dropwise to a cooled, stirred solution of 90 g of 2-chloro-4-hydroxyquinazoline [J. Chem. Soc., 1947, p. 775] in 270 ml of concentrated sulfuric acid at a rate such that the temperature remained at 5°-10° C. Stirring was continued until the reaction mixture reached room temperature, whereupon it was poured into crushed ice. The 2-chloro-4-hydroxy-6-nitro-quinazoline thus precipitated is filtered off, washed well with water and used directly in the next step.

Provenance & Evidence