Potassium Hydroxide → HCID 20524185, compound

Participants

Reaction Steps

Thus obtained ethyl 2-[2-(N-methyl-N-phenylcarbamoyl)phenoxy]acetate (18.23 g.) was added to 10% solution of potassium hydroxide in methanol (2 parts) and water (1 part), and the solution was stirred at room temperature for an hour and allowed to stand overnight. After concentrating the solution under reduced pressure, ethyl acetate was added to the concentrate. After shaking sufficiently, the aqueous solution was separated, acidified with 10% hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, dried and concentrated under reduced pressure to give crystals (13.21 g.) of 2-[2-(N-methyl-N-phenylcarbamoyl)phenoxy]acetic acid.

Provenance & Evidence