Sodium borohydride → HCID 20524477, compound

HRID 1703002Notes

Reaction equation

HRID 1703002 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:32]=[CH:31][CH:30]=[CH:29][C:5]=1[C:6]([NH:8][C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH:19]([C:26](=[O:28])[CH3:27])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1)=[O:10])=[O:7]>O.[OH-].[Na+].C(O)C>[Cl:3][C:4]1[CH:32]=[CH:31][CH:30]=[CH:29][C:5]=1[C:6]([NH:8][C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:26]([OH:28])[CH3:27])=[CH:16][CH:17]=1)=[O:10])=[O:7]

Participants

6

Reactant 2

HCID 4311764Sodium borohydrideHCID 20524537HCID 20524537, compound

Product 1

HCID 20524477HCID 20524477, compoundYield 58.4%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 0.1 g of sodiumborohydride in a mixture of 0.5 ml of water and 0.1 ml of 2 N sodium hydroxide solution was added to a suspension of 1.55 g of N-(2-chlorobenzoyl)-N'-[4-(α-acetylbenzyloxy)phenyl]urea obtained according to the method described in example 1, in 20 ml of ethanol. After stirring for another hour at room temperature the precipitate was sucked off, washed with ethanol and dried; 0.91 g of the desired product was obtained with a melting range of 142°-144° C.

Workup

  1. customobtained
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-3f5a7fc207ef49bfb00d1cc1fd8dc1a0
Source dataset
uspto-grants-1982_09
Patent number
US04350706

Reaction notes

Loading…