HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzocaine → Ethyl 4-[(7-phenylheptyl)amino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | 7-Phenyl-1-heptyl chloride | HCID 522410 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | Ethyl 4-[(7-phenylheptyl)amino]benzoate | HCID 13079667 | — |
Reaction Steps
A mixture of 8.25 g. of ethyl p-aminobenzoate, 5.06 g. of 7-phenylheptylchloride, 3.6 g. of sodium iodide and 25 ml. of hexamethylphosphoramide is heated in an oil bath at 110° C. for 20 hours. The mixture is chilled, diluted with 30 ml. of ethanol-water (1:1) and with water to give crystals, m.p. 65°-67° C. Recrystallization from ethanol gives white crystals, m.p. 66.5°-68° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04350822 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-5553a517e07940cbaccf0a4a1c818145 |
| Source note | uspto-grants-1982_09 |