反应详情

A mixture of 14.5 g. of ethyl p-aminobenzoate, 10 g. of 1-bromo-3-(o-methoxyphenyl)propane and 50 ml. of hexamethylphosphoramide is heated at 130° C. for 15 hours, cooled and diluted with 20 ml. of water. The mixture is chilled, diluted with 50 ml. of cold ethanol:H2O (1:1) and filtered. The solid is washed with three 50 ml. portions of cold ethanol-water (1:1) and with water to give crystals, m.p. 106°-109° C. Recrystallization from ethanol (100 ml.) gives yellow crystals, m.p. 111°-113° C.

1. additionA mixture of 14.5 g
2. temperaturecooled
3. additiondiluted with 20 ml
4. temperatureThe mixture is chilled
5. additiondiluted with 50 ml
6. filtrationof cold ethanol:H2O (1:1) and filtered
7. washThe solid is washed with three 50 ml
8. customportions of cold ethanol-water (1:1) and with water to give crystals, m.p. 106°-109° C
9. customRecrystallization from ethanol (100 ml.)
10. customgives yellow crystals, m.p. 111°-113° C.