反应详情

A mixture of 7.0 g. of ethyl p-[3-(o-methoxyphenyl)propyl]aminobenzoate (prepared as described in Example 41), 7.0 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3.5 hours, acidified while hot with concentrated hydrochloric acid, diluted with water and chilled. The mixture is filtered and the solid washed with water to give off-white crystals, m.p. 155°-157° C. Recrystallization from ethanol gives off-white crystals, m.p. 156°-158° C.

1. additionA mixture of 7.0 g
2. temperaturechilled
3. filtrationThe mixture is filtered
4. washthe solid washed with water
5. customto give off-white crystals, m.p. 155°-157° C
6. customRecrystallization from ethanol
7. customgives off-white crystals, m.p. 156°-158° C.